Article
Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel.
Proceedings. Biological sciences - 22 May 1991
Konno T, Busch C, Von Kitzing E, Imoto K, Wang F, Nakai J, Mishina M, Numa S, Sakmann B
Abstract excerpt
To gain an insight into the molecular basis of the weak but significant selectivity among alkali metal cations of the nicotinic acetylcholine receptor (AChR) channel, we have determined single-channel conductance and permeability ratios for alkali metal cations on specifically mutated Torpedo cal...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- DNA
- Electric Conductivity
- Energy Metabolism
- Molecular Sequence Data
- Mutation
- Potassium
- Receptors, Cholinergic
- Torpedo