Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.

doi:10.1085/jgp.100.3.373

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Article

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.

The Journal of general physiology - 1 Sept 1992

Cohen B N, Labarca C, Davidson N, Lester H A

Abstract excerpt

We measured the permeability ratios (PX/PNa) of 3 wild-type, 1 hybrid, 2 subunit-deficient, and 22 mutant nicotinic receptors expressed in Xenopus oocytes for alkali metal and organic cations using shifts in the bi-ionic reversal potential of the macroscopic current. Mutations at three positions...

Topics

Amino Acid Sequence
Ammonia
Animals
Cations
Cell Membrane Permeability
Cesium
Female
Glycine
Guanidine
Guanidines
Lidocaine
Mice
Molecular Sequence Data
Mutation
Oocytes
Receptors, Nicotinic
Sodium
Temperature

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