Location of a threonine residue in the alpha-subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel.

doi:10.1098/rspb.1991.0012

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Article

Location of a threonine residue in the alpha-subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel.

Proceedings. Biological sciences - 22 Jan 1991

Villarroel A, Herlitze S, Koenen M, Sakmann B

Abstract excerpt

By the combination of cDNA manipulation and functional analysis of normal and mutant acetylcholine receptor (AChR) channels of Torpedo expressed in Xenopus laevis oocytes determinants of ion flow were localized in the bends bordering the putative M2 transmembrane segment (Imoto et al. 1988). We n...

Topics

Animals
Cations
DNA
Electric Conductivity
Female
Ion Channels
Mutation
Oocytes
Protein Conformation
Rats
Receptors, Cholinergic
Threonine
Xenopus laevis

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