Article
Clinical consequences of ADRbeta2 polymorphisms.
Pharmacogenomics - 1 Mar 2008
Hawkins Gregory A, Weiss Scott T, Bleecker Eugene R
Abstract excerpt
The most prescribed medication for controlling bronchoconstriction associated with asthma and chronic obstructive pulmonary disease are beta-agonists. The gene ADRbeta2 encodes the beta-2-adrenergic receptor and contains several common genetic variations that affect gene expression and receptor function in vitro. The ADRbeta2 variations Gly(16)Arg and Gln(27)Glu and, more recently, haplotypic variations, have...
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