Article
Isoform specific phosphorylation of p53 by protein kinase CK1.
Cellular and molecular life sciences : CMLS - 1 Apr 2010
Venerando Andrea, Marin Oriano, Cozza Giorgio, Bustos Victor H, Sarno Stefania, Pinna Lorenzo Alberto
Abstract excerpt
The ability of three isoforms of protein kinase CK1 (alpha, gamma(1), and delta) to phosphorylate the N-terminal region of p53 has been assessed using either recombinant p53 or a synthetic peptide reproducing its 1-28 sequence. Both substrates are readily phosphoylated by CK1delta and CK1alpha, b...
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