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Article

Protection against<i>Leptospira interrogans</i>Sensu Lato Challenge by DNA Immunization with the Gene Encoding Hemolysin-Associated Protein 1

22 Jun 2005

Abstract excerpt

The use of DNA constructs encoding leptospiral proteins is a promising new approach for vaccination against leptospirosis. In previous work we determined that immunization with hemolysis-associated protein 1 (Hap1) (LipL32) expressed by adenovirus induced significant protection against a virulent Leptospira challenge in gerbils. To avoid the use of the adenovirus vector, we checked for clinical protection against...

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Identifiers

PMID: 15972494
DOI: 10.1128/iai.73.7.4062-4069.2005

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