Comparison of antibody and protective immune responses against <i>Trypanosoma cruzi</i> infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant protein

Abstract excerpt

Immunization with naked DNA represents an attractive strategy for development of vaccines against a variety of infections including those caused by protozoan parasites. Recently, we have described that immunization with a plasmid containing the trans-sialidase (TS) gene induced protective immunity against Trypanosoma cruzi infection in BALB/c mice. The present study was aimed at examining and comparing the...

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