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Article

Identification of the Hemolysis-Associated Protein 1 as a Cross-Protective Immunogen of<i>Leptospira interrogans</i>by Adenovirus-Mediated Vaccination

1 Nov 2001

Abstract excerpt

New vaccine strategies are needed for the prevention of leptospirosis, a widespread human and animal disease caused by pathogenic leptospires. Our previous work determined that a protein leptospiral extract conferred cross-protection in a gerbil model of leptospirosis. The 31- to 34-kDa protein fraction of Leptospira interrogans serovar autumnalis was shown sufficient for this purpose. In the present study,...

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Identifiers

PMID: 11598056
DOI: 10.1128/iai.69.11.6831-6838.2001

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