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Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidates

7 Oct 2022

Abstract excerpt

Leptospirosis is a neglected disease of man and animals that affects nearly half a million people annually and causes considerable economic losses. Current human vaccines are inactivated whole-cell preparations (bacterins) of Leptospira spp. that provide strong homologous protection yet fail to induce a cross-protective immune response. Yearly boosters are required, and serious side-effects are frequently...

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PMID: 36275031
DOI: 10.3389/fcimb.2022.940966

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