Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans

13 Dec 2011

Abstract excerpt

The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determined the minimum number and location of LigA domains required for immunoprotection. Immunization with domains 11 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leptospirosis research and findings
Share to Viral Infections and Vectors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22180800
DOI: 10.1371/journal.pntd.0001422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogansPMID 22180800Read ↗

Leptospiral Immunoglobulin-Like Domain Proteins: Roles in Virulence and ImmunitySemantic proximity Read ↗

A Conserved Region of Leptospiral Immunoglobulin-Like A and B Proteins as a DNA Vaccine Elicits a Prophylactic Immune Response against LeptospirosisSemantic proximity Read ↗

Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp.Semantic proximity Read ↗

Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidatesSemantic proximity Read ↗

Evaluation of LipL32 and LigA/LigB Knockdown Mutants in Leptospira interrogans Serovar Copenhageni: Impacts to Proteome and VirulenceSemantic proximity Read ↗

Expression of leptospiral immunoglobulin-like protein by Leptospira interrogans and evaluation of its diagnostic potential in a kinetic ELISASemantic proximity Read ↗

Predicted epitopes of Lig A of Leptospira interrogans by bioinformatics method: a clue for further vaccine development.Semantic proximity Read ↗

Distribution of the leptospiral immunoglobulin-like (lig) genes in pathogenic Leptospira species and application of ligB to typing leptospiral isolatesSemantic proximity Read ↗

Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and KidneySemantic proximity Read ↗

The C-terminal variable domain of LigB fromLeptospiramediates binding to fibronectinSemantic proximity Read ↗

Discovery of Novel Leptospirosis Vaccine Candidates Using Reverse and Structural VaccinologySemantic proximity Read ↗

Chimeric lipoproteins for leptospirosis vaccine: immunogenicity and protective potentialSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.