Article

Leptospira Lipid a Is a Potent Adjuvant Capable of Inducing Antigen-Specific Sterilizing Immunity Against Leptospirosis

2023-07-20

Abstract excerpt

Leptospirosis is a zoonotic disease of global importance. The current killed vaccine provides serovar-specific protection without sterilizing immunity. Several surface antigens, including Leptospira immunoglobulin-like proteins (LigA and LigB), have been identified as subunit vaccine candidates; however, they require potent adjuvants. Bacterial Lipopolysaccharide (LPS), including lipid A, is a well-known immunosti...

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Literature Corpus work: 6ae7d845-642a-5597-ac98-60a0261be049
DOI: 10.20944/preprints202307.1446.v1

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