Sialylation of Group B Streptococcal Capsular Polysaccharide Is Mediated by<i>cpsK</i>and Is Required for Optimal Capsule Polymerization and Expression

Abstract excerpt

Several bacterial pathogens have evolved the means to escape immune detection by mimicking host cell surface carbohydrates that are crucial for self/non-self recognition. Sialic acid, a terminal residue on these carbohydrates, inhibits activation of the alternate pathway of complement by recruiting the immune modulating molecule factors H, I, and iC3b. Sialylation of capsular polysaccharide (CPS) is important for...

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