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Sialic acid involved in hypermucoviscosity phenotype of<i>Klebsiella pneumoniae</i>and associated with resistance to neutrophil phagocytosis

5 Aug 2014

Abstract excerpt

Klebsiella pneumoniae (KP) with the hypermucoviscosity (HV) phenotype has abundant capsular polysaccharides (CPS) and usually causes an invasive syndrome. Sialic acid (Sia), a component of CPS in KP strains with the HV phenotype, may be anti-phagocytic. Sia-binding immunoglobulin-like lectin-9 (Siglec-9) act as an MHC class-I receptor on neutrophils that recognizes Sia and sends a signal to dampen inflammatory...

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PMID: 25098744
DOI: 10.4161/viru.32076

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