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Article

Effect of somatic mutation on DNA binding properties of anti-DNA autoantibodies.

Biopolymers - 1 Jan 2000

Bobeck Melissa J, Cleary Joanne, Beckingham Jenny A, Ackroyd P Christine, Glick Gary D

Abstract excerpt

Autoantibodies that bind DNA are a hallmark of systemic lupus erythematosus. A subset of autoantibody*DNA complexes localize to kidney tissue and lead to damage and even death. 11F8, 9F11, and 15B10 are clonally related anti-DNA autoantibodies isolated from an autoimmune mouse. 11F8 binds ssDNA in a sequence-specific manner and causes tissue damage, while 9F11 and 15B10 bind ssDNA non-specifically and are benign....

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Share to Antibodies, Antinuclear
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17252585
DOI: 10.1002/bip.20691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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