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Article

Selection of recurrent V genes and somatic mutations in autoantibodies to DNA.

Methods (San Diego, Calif.) - 1 Jan 1997

Radic M Z, Seal S N

Abstract excerpt

Antigen selection of autoantibodies to DNA results in the use of limited sets of immunoglobulin heavy and light chains, characteristic VDJ and VJ joining regions, and recurrent patterns of somatic mutations. In the past, we have used site-directed mutagenesis to examine the roles of two recurrent features of anti-DNA antibodies: VHCDR3 arginine and somatic mutations to arginine. We observed that in one prototypic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

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Share to Mutagenesis, Site-Directed

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Source

Identifiers

PMID: 8990085
DOI: 10.1006/meth.1996.0383

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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