Article
Selection of recurrent V genes and somatic mutations in autoantibodies to DNA.
Methods (San Diego, Calif.) - 1 Jan 1997
Radic M Z, Seal S N
Abstract excerpt
Antigen selection of autoantibodies to DNA results in the use of limited sets of immunoglobulin heavy and light chains, characteristic VDJ and VJ joining regions, and recurrent patterns of somatic mutations. In the past, we have used site-directed mutagenesis to examine the roles of two recurrent...
Topics
- Antibodies, Antinuclear
- Autoantibodies
- Binding Sites
- Immunoglobulin Variable Region
- Lupus Erythematosus, Systemic
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Protein Binding