Article
Colorectal cancer "methylator phenotype": fact or artifact?
Neoplasia (New York, N.Y.) - 1 Apr 2005
Anacleto Charles, Leopoldino Andréia M, Rossi Benedito, Soares Fernando A, Lopes Ademar, Rocha José Cláudio C, Caballero Otávia, Camargo Anamaria A, Simpson Andrew J G, Pena Sérgio D J
Abstract excerpt
It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP)," characterized by preferential proximal location in the colon, but otherwise poorly defined. There is considerable overlap between this putative methylator phenotype and the well-known mutator...
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