Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer.

International journal of cancer - 15 Nov 2006

Iacopetta Barry, Grieu Fabienne, Li Wei, Ruszkiewicz Andrew, Caruso Maria, Moore James, Watanabe Goh, Kawakami Kazuyuki

Abstract excerpt

The notion of a CpG island methylator phenotype (CIMP) was proposed to describe a subset of colorectal cancers (CRC) displaying frequent and concordant methylation of CpG islands located within gene promoter regions. Some workers have failed to observe associations between CIMP and specific clinicopathological features of CRC, possibly because of the choice of genes used to define this phenotype. The aim of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Genes, APC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p16

Share to MutL Protein Homolog 1

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Share to Tissue Inhibitor of Metalloproteinase-3

Source

Identifiers

PMID: 16981189
DOI: 10.1002/ijc.22237

Genes

APC
TIMP3
MLH1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer.PMID 16981189Read ↗

DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer.Semantic proximity Read ↗

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies.Semantic proximity Read ↗

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.Semantic proximity Read ↗

MLH1 gene promoter methylation status partially overlaps with CpG methylator phenotype (CIMP) in colorectal adenocarcinomaSemantic proximity Read ↗

Colorectal cancer "methylator phenotype": fact or artifact?Semantic proximity Read ↗

BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients.Semantic proximity Read ↗

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.Semantic proximity Read ↗

CpG island methylator phenotype (CIMP) in cancer: causes and implications.Semantic proximity Read ↗

No association of CpG island methylator phenotype and colorectal cancer survival: population-based study.Semantic proximity Read ↗

Promoter methylation of specific genes is associated with the phenotype and progression of colorectal adenocarcinomas.Semantic proximity Read ↗

Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands.Semantic proximity Read ↗

Meta-analysis of the prognostic value of CpG island methylator phenotype in rectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.