Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells.

The Journal of biological chemistry - 15 Feb 2002

Tang Hua, Hao Qin, Fitzgerald Trinita, Sasaki Terukatsu, Landon Erwin J, Inagami Tadashi

Abstract excerpt

Endothelial cell spreading, migration, and morphogenesis are essential for angiogenesis, the formation of new blood vessels. In the present study, we explored roles of tyrosine kinase Pyk2 in angiogenesis of pulmonary endothelial cells. We found that tyrosine kinase Pyk2 was particularly enriched in pulmonary vascular endothelial cells and lung, a major organ site for tumor metastasis. By using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Adenoviridae
Share to Endothelium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Focal Adhesion Kinase 1

Share to Focal Adhesion Kinase 2

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Neovascularization, Physiologic

Source

Identifiers

PMID: 11739395
DOI: 10.1074/jbc.M110673200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells.PMID 11739395Read ↗

Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and CancerSemantic proximity Read ↗

EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2Semantic proximity Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development and TherapySemantic proximity Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer DevelopmentSemantic proximity Read ↗

The tyrosine kinase pyk2 promotes migration and invasion of glioma cells.Semantic proximity Read ↗

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and FunctionSemantic proximity Read ↗

Identification of Protein Kinase D2 as a Pivotal Regulator of Endothelial Cell Proliferation, Migration, and AngiogenesisSemantic proximity Read ↗

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.Semantic proximity Read ↗

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation.Semantic proximity Read ↗

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.Semantic proximity Read ↗

PTK2-associated gene signature could predict the prognosis of IPFSemantic proximity Read ↗

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.