Article
Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells.
The Journal of biological chemistry - 15 Feb 2002
Tang Hua, Hao Qin, Fitzgerald Trinita, Sasaki Terukatsu, Landon Erwin J, Inagami Tadashi
Abstract excerpt
Endothelial cell spreading, migration, and morphogenesis are essential for angiogenesis, the formation of new blood vessels. In the present study, we explored roles of tyrosine kinase Pyk2 in angiogenesis of pulmonary endothelial cells. We found that tyrosine kinase Pyk2 was particularly enriched in pulmonary vascular endothelial cells and lung, a major organ site for tumor metastasis. By using...
Topics
- 3T3 Cells
- Adaptor Proteins, Signal Transducing
- Adenoviridae
- Animals
- CHO Cells
- Cell Adhesion
- Cell Line
- Cell Movement
- Cells, Cultured
- Cricetinae
- Endothelium
- Endothelium, Vascular
- Focal Adhesion Kinase 1
- Focal Adhesion Kinase 2