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Article

Loss of PLK2 induces acquired resistance to temozolomide in GBM via activation of notch signaling

11 Nov 2020

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is a lethal type of primary brain tumor with a median survival less than 15 months. Despite the recent improvements of comprehensive strategies, the outcomes for GBM patients remain dismal. Accumulating evidence indicates that rapid acquired chemoresistance is the major cause of GBM recurrence thus leads to worse clinical outcomes. Therefore, developing novel biomarkers and...

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PMID: 33176854
DOI: 10.1186/s13046-020-01750-4

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