Article
p73gamma transactivates the p21 promoter through preferential interaction with the p300/CBP-associated factor in human prostate cancer cells.
Oncology reports - 1 Aug 2007
Momii Yasutomo, Izumi Hiroto, Shiota Masaki, Onitsuka Takamitsu, Abe Tatsuya, Kobayashi Hidenori, Miyamoto Naoya, Uchiumi Takeshi, Kohno Kimitoshi
Abstract excerpt
Several p73 variants have been reported with different carboxy-terminal structures and transcriptional activities. We showed that p73gamma had stronger transactivation activity than the other splicing variants such as alpha, beta and delta by analysing p21 promoter activity in human prostate cancer PC3 cells. The transactivation activity of p73gamma was similar to that of p53 and was enhanced by co-transfection...
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