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Neutrophil granules in health and disease

28 Apr 2010

Abstract excerpt

Neutrophil granules store proteins that are critically important for the neutrophil to move from the vascular bed to tissues and to kill microorganisms. This is illustrated in nature when individual proteins are deleted due to inherited mutations of their cognate genes, and such deficiencies result in the conditions leucocyte adhesion deficiency and chronic granulomatous disease. The granules of the neutrophil...

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PMID: 20497300
DOI: 10.1111/j.1365-2796.2010.02237.x

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