Article
Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets.
Journal of thrombosis and haemostasis : JTH - 1 May 2014
Glembotsky A C, Bluteau D, Espasandin Y R, Goette N P, Marta R F, Marin Oyarzun C P, Korin L, Lev P R, Laguens R P, Molinas F C, Raslova H, Heller P G
Abstract excerpt
BACKGROUND: Familial platelet disorder with a predisposition to acute myelogenous leukemia (FPD/AML) is an inherited platelet disorder caused by a germline RUNX1 mutation and characterized by thrombocytopenia, a platelet function defect, and leukemia predisposition. The mechanisms underlying FPD/AML platelet dysfunction remain incompletely clarified. We aimed to determine the contribution of platelet structural...
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