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Article

Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha.

Hepatology (Baltimore, Md.) - 1 Jul 2005

Nagakawa Yuichi, Williams George Melville, Zheng Qizhi, Tsuchida Akihiko, Aoki Tatsuya, Montgomery Robert A, Klein Andrew S, Sun Zhaoli

Abstract excerpt

An orthotopic liver transplant model in the rat was used to evaluate the role of tumor necrosis factor alpha (TNF-alpha) in liver transplant rejection. There were significantly increased levels of TNF-alpha mRNA and parallel increases in 8-hydroxy-2' deoxyguanosine (8-OHdG) indicative of oxidative DNA damage present 7 to 12 days after transplantation. Cells staining positively for 8-OHdG were localized to the...

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PMID: 15962292
DOI: 10.1002/hep.20755

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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