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The role of hepatocyte mitochondrial DNA in liver injury

14 Oct 2023

Abstract excerpt

Hepatocytes, the predominant cellular constituents of the liver, exhibit the highest mitochondrial density within the human body. Remarkably, experimental insights from the latter part of the previous century involving extracellular injection of mitochondrial DNA (mtDNA) elucidated its potential to incite autoimmune disorders. Consequently, in instances of liver injury, the substantial release of mtDNA has the...

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PMID: 37844357
DOI: 10.1016/j.biopha.2023.115692

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