Article
Tumor necrosis factor-alpha promoter polymorphisms and the risk of rejection after liver transplantation: a case control analysis of 210 donor-recipient pairs.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Apr 2003
Jazrawi Saad F, Zaman Atif, Muhammad Zafaruddin, Rabkin John M, Corless Christopher L, Olyaei Ali, Biggs Amy, Ham John, Chou Sunwen, Rosen Hugo R
Abstract excerpt
After orthotopic liver transplantation (OLT), allograft rejection remains an important problem and is the major reason that immunosuppressive therapy must be administered. Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory mediator that is central to the immune response, and intragraft expression of this cytokine is increased during acute cellular rejection (ACR). Polymorphisms within the TNF promoter...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.