Article
Expression of tumour-specific antigens underlies cancer immunoediting.
Nature - 8 Feb 2012
DuPage Michel, Mazumdar Claire, Schmidt Leah M, Cheung Ann F, Jacks Tyler
Abstract excerpt
Cancer immunoediting is a process by which immune cells, particularly lymphocytes of the adaptive immune system, protect the host from the development of cancer and alter tumour progression by driving the outgrowth of tumour cells with decreased sensitivity to immune attack. Carcinogen-induced mouse models of cancer have shown that primary tumour susceptibility is thereby enhanced in immune-compromised mice,...
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