Article
Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells.
Neoplasia (New York, N.Y.) - 1 Dec 2006
Takahashi Meiko, Yoshimoto Takanobu, Shimoda Masayuki, Kono Tomoya, Koizumi Masayuki, Yazumi Shujiro, Shimada Yutaka, Doi Ryuichiro, Chiba Tsutomu, Kubo Hajime
Abstract excerpt
The importance of genetic mutations in carcinogenesis has been recognized, and it has been proposed that aberrant mutation of mRNA may represent a novel oncogenic principle. Here we report that the mRNA of a homeobox gene prox1, a candidate tumor suppressor, suffers adenosine-to-inosine nucleotide conversion and loses tumor-suppressive functions in a subset of human cancers. Expression of Prox1 was reduced in...
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