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Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours

31 Jan 2018

Abstract excerpt

Testicular germ cell tumour (TGCT) is the most common cancer in young men in large parts of the world, but the aetiology is mainly unknown. Genome-wide association studies have so far identified about 50 susceptibility loci associated with TGCT, including SPRY4. SPRY4 has shown tumour suppressor activity in several cancer cells, such as lung and prostate, while it was found to act as an oncogene in ovarian...

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PMID: 29410498
DOI: 10.1038/s41598-018-20846-8

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Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumoursPMID 29410498Read ↗

Role of SPRY4 in health and diseaseSemantic proximity Read ↗

Up-Regulated Expression of SPRY4-IT1 Predicts Poor Prognosis in Colorectal CancerSemantic proximity Read ↗

Long noncoding RNA <em>SPRY4-IT1</em> promotes malignant development of colorectal cancer by targeting epithelial&ndash;mesenchymal transitionSemantic proximity Read ↗

Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transitionSemantic proximity Read ↗

Hypomethylation-driven AKT Serine/Threonine Kinase 3 promotes testicular germ cell tumors proliferation and negatively correlates to immune infiltration.Semantic proximity Read ↗

LncRNA SPRY4‐IT1 facilitates cell proliferation and angiogenesis of glioma via the miR‐101‐3p/EZH2/VEGFA signaling axisSemantic proximity Read ↗

Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial–mesenchymal transitionSemantic proximity Read ↗

Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.Semantic proximity Read ↗

Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testisSemantic proximity Read ↗

SPRY4 inhibits and sensitizes the primary KIT mutants in gastrointestinal stromal tumors (GISTs) to imatinib.Semantic proximity Read ↗

CSNK1G2-AS1 promotes metastasis, colony formation and serves as a biomarker in testicular germ cell tumor cellsSemantic proximity Read ↗

Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.Semantic proximity Read ↗

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