Article
Genetic targeting of relaxin and insl3 signaling in mice.
Annals of the New York Academy of Sciences - 1 May 2005
Feng Shu, Bogatcheva Natalia V, Kamat Aparna A, Agoulnik Alexander I
Abstract excerpt
We studied ligand-receptor interactions between relaxin (RLN), insulin-like 3 peptide (INSL3), and LGR7 and LGR8 receptors. The phenotypic effects of deficiency for Lgr7 and Lgr8 receptors, transgenic overexpression of Rln1 and Insl3, and different combinations of these mutations in mice were analyzed. It was reported that Rln1-deficient mice exhibit abnormal nipple development, prolonged parturition, age-related...
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