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Article

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.

The Journal of biological chemistry - 30 Aug 2002

Kumagai Jin, Hsu Sheau Yu, Matsumi Hirotaka, Roh Jae-Sook, Fu Ping, Wade John D, Bathgate Ross A D, Hsueh Aaron J W

Abstract excerpt

Several orphan G protein-coupled receptors homologous to gonadotropin and thyrotropin receptors have recently been identified and named as LGR4-8. INSL3, also known as Leydig insulin-like peptide or relaxin-like factor, is a relaxin family member expressed in testis Leydig cells and ovarian theca and luteal cells. Male mice mutant for INSL3 exhibit cryptorchidism or defects in testis descent due to abnormal...

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Source

Identifiers

PMID: 12114498
DOI: 10.1074/jbc.C200398200

Genes

INSL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.PMID 12114498Read ↗

GREAT/LGR8 is the only receptor for insulin-like 3 peptide.Semantic proximity Read ↗

INSL3/RXFP2 Signaling in Testicular DescentSemantic proximity Read ↗

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1Semantic proximity Read ↗

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

Insulin‐like 3 signalling in testicular descentSemantic proximity Read ↗

Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiologySemantic proximity Read ↗

The molecular basis of cryptorchidism.Semantic proximity Read ↗

Genetic targeting of relaxin and insl3 signaling in mice.Semantic proximity Read ↗

Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.Semantic proximity Read ↗

Insulin-Like 3 Exposure of the Fetal Rat Gubernaculum Modulates Expression of Genes Involved in Neural Pathways1Semantic proximity Read ↗

The Orphan Nuclear Receptor NR4A1 Regulates Insulin-Like 3 Gene Transcription in Leydig Cells1Semantic proximity Read ↗

Role of INSL3 and LGR8 in cryptorchidism and testicular functions.Semantic proximity Read ↗

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