Article
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
Brain research. Molecular brain research - 13 Sept 2005
Oterino Agustín, Valle Natalia, Pascual Julio, Bravo Yolanda, Muñoz Pedro, Castillo Jesús, Ruiz-Alegría Carlos, Sánchez-Velasco Pablo, Leyva-Cobián Francisco, Cid Carmen
Abstract excerpt
There is growing evidence that folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura. Even though folate metabolism is regulated by a number of enzymes, only two functional polymorphisms have been tested in association studies with migraine. Here, we have explored the possible role in migraine of other folate-metabolizing enzymes which are in close interdependency with...
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