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Article

The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura.

BMC medicine - 12 Feb 2004

Lea Rod A, Ovcaric Micky, Sundholm James, MacMillan John, Griffiths Lyn R

Abstract excerpt

BACKGROUND: The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that may also be affected by genetically influenced hyperhomocysteinaemia. To determine whether the C677T variant in the...

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Source

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Identifiers

PMID: 15053827
DOI: 10.1186/1741-7015-2-3
PMCID: PMC375543

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura.PMID 15053827Read ↗

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