Association study of MTHFD1 coding polymorphisms R134K and R653Q with migraine susceptibility.

doi:10.1111/head.12428

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Article

Association study of MTHFD1 coding polymorphisms R134K and R653Q with migraine susceptibility.

Headache - 1 Oct 2014

Sutherland Heidi G, Hermile Heloise, Sanche Rebecca, Menon Saras, Lea Rod A, Haupt Larisa M, Griffiths Lyn R

Abstract excerpt

OBJECTIVE: There is evidence that folate metabolism has a role in migraine pathophysiology, particularly in the migraine with aura (MA) subtype. In this study, we investigate whether two non-synonymous single nucleotide polymorphisms (SNPs), rs1950902 (C401T; R134K) and rs2236225 (G1958A; R653Q), in MTHF dehydrogenase (MTHFD1) are associated with migraine in an Australian case-control population. BACKGROUND:...

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Identifiers

PMID: 25039261
DOI: 10.1111/head.12428

Genes

MTHFD1
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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