Article
The biochemistry of Parkinson's disease.
Annual review of biochemistry - 1 Jan 2005
Cookson Mark R
Abstract excerpt
Several genes have been identified for monogenic disorders that variably resemble Parkinson's disease. Dominant mutations in the gene encoding alpha-synuclein enhance the propensity of this protein to aggregate. As a consequence, these patients have a widespread disease with protein inclusion bodies in several brain areas. In contrast, mutations in several recessive genes (parkin, DJ-1, and PINK1) produce...
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