Article
Genetics of Parkinson's disease.
Annals of medicine - 1 Jan 2005
Morris Huw R
Abstract excerpt
Twenty years ago Parkinson's disease (PD) was thought of as an environmentally determined neurodegenerative disease. It is now known that there are two autosomal dominant disease genes, alpha-synuclein and dardarin, and three genes responsible for autosomal recessive PD, parkin, DJ-1 and PINK-1. Although these gene mutations are not common, their identification has led to a new understanding of the pathogenesis...
Topics
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Intracellular Signaling Peptides and Proteins
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lewy Body Disease
- Mutation
- Nerve Tissue Proteins
- Oncogene Proteins
- Parkinson Disease
- Protein Deglycase DJ-1
- Protein Kinases
- Protein Serine-Threonine Kinases
- Synucleins
- Ubiquitin-Protein Ligases
- alpha-Synuclein