Article
Genetic basis of Parkinson disease.
Neurosurgical focus - 1 Jan 2010
Xiromerisiou Georgia, Dardiotis Efthimios, Tsimourtou Vaïa, Kountra Persa Maria, Paterakis Konstantinos N, Kapsalaki Eftychia Z, Fountas Kostas N, Hadjigeorgiou Georgios M
Abstract excerpt
Over the past few years, considerable progress has been made in understanding the molecular mechanisms of Parkinson disease (PD). Mutations in certain genes are found to cause monogenic forms of the disorder, with autosomal dominant or autosomal recessive inheritance. These genes include alpha-synuclein, parkin, PINK1, DJ-1, LRRK2, and ATP13A2. The monogenic variants are important tools in identifying cellular...
Topics
- Deep Brain Stimulation
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Intracellular Signaling Peptides and Proteins
- Mutation
- Mutation, Missense
- Oncogene Proteins
- Parkinson Disease