Article
Etiology and pathogenesis of Parkinson disease.
Neurologic clinics - 1 Aug 2009
Schapira Anthony H V
Abstract excerpt
The etiology of Parkinson disease (PD) is multifactorial and is likely to involve different causes in different patients. Several different genes have been identified as causes of familial PD, including alpha-synuclein gene mutations and multiplications, and mutations of parkin, PINK1, DJ1, and LRRK2. The biochemical consequences of these mutations have served to reinforce the relevance of the pathways to...
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