Article
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.
The Journal of biological chemistry - 12 Aug 2005
Valiente Miguel, Andrés-Pons Amparo, Gomar Beatriz, Torres Josema, Gil Anabel, Tapparel Caroline, Antonarakis Stylianos E, Pulido Rafael
Abstract excerpt
The tumor suppressor phosphatase PTEN is a key regulator of cell growth and apoptosis that interacts with PDZ domains from regulatory proteins, including MAGI-1/2/3, hDlg, and MAST205. Here we identified novel PTEN-binding PDZ domains within the MAST205-related proteins, syntrophin-associated serine/threonine kinase and MAST3, characterized the regions of PTEN involved in its interaction with distinctive PDZ...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.