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Article

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity.

Biomolecules - 1 Feb 2025

Yanik Tulin, Durhan Seyda Tugce

Abstract excerpt

Genetic obesity results from loss-of-function mutations, including those affecting the leptin-melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating the leptin-melanocortin pathway through protein-protein interactions. Loss-of-function mutations in the genes encoding POMC, MC3R, and MC4R can lead to the...

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Source

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Identifiers

PMID: 40001512
DOI: 10.3390/biom15020209
PMCID: PMC11853658

Genes

POMC
MC4R
MC3R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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