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Article

The Melanocortin 4 Receptor p.Ile269Asn Mutation Is Associated with Childhood and Adult Obesity in Mexicans.

The Journal of clinical endocrinology and metabolism - 1 Apr 2020

Vázquez-Moreno Miguel, Zeng Helen, Locia-Morales Daniel, Peralta-Romero Jesús, Asif Hamza, Maharaj Arjuna, Tam Vivian, Romero-Figueroa María D S, Sosa-Bustamante Gloria P, Méndez-Martínez Socorro, Mejía-Benítez Aurora, Valladares-Salgado Adan, Wacher-Rodarte Niels, Cruz Miguel, Meyre David

Abstract excerpt

CONTEXT: Rare partial/complete loss-of-function mutations in the melanocortin-4 receptor (MC4R) gene are the most common cause of Mendelian obesity in European populations, but their contribution to obesity in the Mexican population is unclear. OBJECTIVE AND DESIGN: We investigated whether deleterious mutations in MC4R contribute to obesity in Mexican children and adults. RESULTS: We provide evidence that the...

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Identifiers

PMID: 31841602
DOI: 10.1210/clinem/dgz276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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