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Article

RNAi knockdown of PIK3CA preferentially inhibits invasion of mutant PIK3CA cells.

World journal of gastroenterology - 28 Aug 2011

Zhou Xin-Ke, Tang Sheng-Song, Yi Gao, Hou Min, Chen Jin-Hui, Yang Bo, Liu Ji-Fang, He Zhi-Min

Abstract excerpt

AIM: To explore the effects of siRNA silencing of PIK3CA on proliferation, migration and invasion of gastric cancer cells and to investigate the underlying mechanisms. METHODS: The mutation of PIK3CA in exons 9 and 20 of gastric cancer cell lines HGC-27, SGC-7901, BGC-823, MGC-803 and MKN-45 was screened by polymerase chain reaction (PCR) followed by sequencing. BGC-823 cells harboring no mutations in either of...

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Identifiers

PMID: 21990951
DOI: 10.3748/wjg.v17.i32.3700
PMCID: PMC3181455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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