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Article

The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis.

Genes & development - 1 May 1999

Lu Y, Settleman J

Abstract excerpt

The PKN family of PKC-related protein kinases constitutes the major Rho GTPase-associated protein kinase activities detected in mammalian tissues. However, the biological functions of these kinases are unknown. We have identified a closely related PKN homolog in Drosophila (Pkn) that binds specifically to GTP-activated Rho1 and Rac1 GTPases through distinct binding sites on Pkn. The interaction of Pkn with either...

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Identifiers

PMID: 10323867
DOI: 10.1101/gad.13.9.1168
PMCID: PMC316938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis.PMID 10323867Read ↗

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