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Article

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

Science signaling - 13 Feb 2018

Kroeger Heike, Grimsey Neil, Paxman Ryan, Chiang Wei-Chieh, Plate Lars, Jones Ying, Shaw Peter X, Trejo JoAnn, Tsang Stephen H, Powers Evan, Kelly Jeffery W, Wiseman R Luke, Lin Jonathan H

Abstract excerpt

ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion of the isoform activating transcription factor 6α (ATF6α) and its paralog ATF6β results in embryonic lethality and notochord dysgenesis in nonhuman vertebrates, and loss-of-function mutations in ATF6α are associated with malformed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29440509
DOI: 10.1126/scisignal.aan5785
PMCID: PMC5957084

Genes

ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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