Article
Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5.
Oncogene - 9 Feb 2006
Angelastro J M, Canoll P D, Kuo J, Weicker M, Costa A, Bruce J N, Greene L A
Abstract excerpt
Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and astrocytes, but is expressed by reactive astrocytes. Interference with ATF5 function or expression...
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