Article
Minimal role for activating transcription factor 3 in the oligodendrocyte unfolded protein response in vivo.
Journal of neurochemistry - 1 Sept 2007
Sharma Ramaswamy, Jiang HuiYuan, Zhong Laura, Tseng James, Gow Alexander
Abstract excerpt
To further our goal of identifying and characterizing the functions of major components of the unfolded protein response (UPR) in oligodendrocytes, the gene encoding the activator of transcription factor 3 protein (ATF3) has been ablated in mice expressing mutant forms of the Proteolipid protein 1 (Plp1) gene and the phenotype of double mutants characterized at several levels. Mature oligodendrocytes in Plp1...
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