Article
Functional MASP2 single nucleotide polymorphism plays no role in psoriasis.
The British journal of dermatology - 1 Jun 2005
Stover C, Barrett S, Lynch N J, Barker J N W N, Burden D, Trembath R, Schwaeble W, Veal C
Abstract excerpt
BACKGROUND: Psoriasis is a heritable disease and genome-wide scans have implicated several loci of susceptibility. The gene for MASP-2, a protease involved in complement activation, is located within one of these loci on chromosome 1p. OBJECTIVES: To assess whether partial or total MASP-2 deficiency is a risk factor for developing psoriasis. METHODS: We screened a cohort of patients affected by plaque psoriasis...
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