Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis.

doi:10.1016/j.jstrokecerebrovasdis.2015.11.041

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Article

Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Mar 2016

Song Yanli, Li Bohong, Wang Chunjuan, Wang Penglian, Gao Xiang, Liu Gaifen

Abstract excerpt

BACKGROUND: Hyperhomocysteinemia, a condition that is strongly determined by dietary intake of B vitamins, has been suggested to be an independent risk factor for ischemic stroke (IS). To test this hypothesis, we performed a meta-analysis to investigate the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which plays a critical role in modulating plasma homocysteine...

Topics

5,10-Methylenetetrahydrofolate Reductase (FADH2)
Brain Ischemia
Case-Control Studies
Chi-Square Distribution
Databases, Bibliographic
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Polymorphism, Single Nucleotide
Stroke

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Identifiers

PMID: 26776436
DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.041

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.