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Article

Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages

10 Jun 2005

Abstract excerpt

Interferon regulatory factor-8 (IRF-8)/interferon consensus sequence-binding protein (ICSBP) is a transcription factor that controls myeloid-cell development. Microarray gene expression analysis of Irf-8-/- myeloid progenitor cells expressing an IRF-8/estrogen receptor chimera (which differentiate into macrophages after addition of estradiol) was used to identify 69 genes altered by IRF-8 during early...

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PMID: 15947094
DOI: 10.1182/blood-2005-01-0080

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