Article
Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60.
The Journal of biological chemistry - 29 Jul 2005
Pushkarsky Tatiana, Yurchenko Vyacheslav, Vanpouille Christophe, Brichacek Beda, Vaisman Iosif, Hatakeyama Shigetsugu, Nakayama Keiichi I, Sherry Barbara, Bukrinsky Michael I
Abstract excerpt
CD147, also known as extracellular matrix metalloproteinase inducer, is a regulator of matrix metalloproteinase production and also serves as a signaling receptor for extracellular cyclophilins. Previously, we demonstrated that cell surface expression of CD147 is sensitive to cyclophilin-binding drug cyclosporin A, suggesting involvement of a cyclophilin in the regulation of intracellular transport of CD147. In...
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