Article
Active site residues of cyclophilin A are crucial for its signaling activity via CD147.
The Journal of biological chemistry - 21 Jun 2002
Yurchenko Vyacheslav, Zybarth Gabriele, O'Connor Matthew, Dai Wei Wei, Franchin Giovanni, Hao Tang, Guo Huiming, Hung Hsiu-Cheng, Toole Bryan, Gallay Philippe, Sherry Barbara, Bukrinsky Michael
Abstract excerpt
Cyclophilin A (CyPA), a ubiquitously distributed intracellular protein, is a peptidylprolyl cis-trans-isomerase and the major target of the potent immunosuppressive drug cyclosporin A. Although expressed predominantly as an intracellular molecule, CyPA is secreted by cells in response to inflammatory stimuli and is a potent neutrophil and eosinophil chemoattractant in vitro and in vivo. The mechanisms underlying...
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